C. A. Sei

Latest

• Myocardial alpha-thrombin receptor activation induces hypertrophy and increases atrial natriuretic factor gene expression.
• Regulated secretion of atrial natriuretic factor from cultured ventricular myocytes.
• Protein kinase C and calmodulin kinase are required for endothelin-stimulated atrial natriuretic factor secretion from primary atrial myocytes.
• The cosecretional maturation of atrial natriuretic factor by primary atrial myocytes.
• Studies of ANF processing and secretion using a primary cardiocyte culture model.
• The alpha-adrenergic stimulation of atrial natriuretic factor expression in cardiac myocytes requires calcium influx, protein kinase C, and calmodulin-regulated pathways.
• Calcium dependence of phenylephrine-, endothelin-, and potassium chloride-stimulated atrial natriuretic factor secretion from long term primary neonatal rat atrial cardiocytes.