Christopher C. Glembotski

Latest

• Optimizing Adeno-Associated Virus Serotype 9 for Studies of Cardiac Chamber-Specific Gene Regulation.
• The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes.
• Proteomic analysis of the cardiac myocyte secretome reveals extracellular protective functions for the ER stress response.
• Simultaneous Isolation and Culture of Atrial Myocytes, Ventricular Myocytes, and Non-Myocytes from an Adult Mouse Heart.
• Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart.
• Designing Novel Therapies to Mend Broken Hearts: ATF6 and Cardiac Proteostasis.
• Reactive Oxygen Species (ROS)-Activatable Prodrug for Selective Activation of ATF6 after Ischemia/Reperfusion Injury.
• The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts.
• ATF6 as a Nodal Regulator of Proteostasis in the Heart.
• Physiological signaling in the absence of amidated peptides.
• Proteostasis and Beyond: ATF6 in Ischemic Disease.
• Unfolding the Roles of Mitochondria as Therapeutic Targets for Heart Disease.
• ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb.
• Integrating ER and Mitochondrial Proteostasis in the Healthy and Diseased Heart.
• Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis.
• Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome.
• ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart.
• Expanding the Paracrine Hypothesis of Stem Cell-Mediated Repair in the Heart: When the Unconventional Becomes Conventional.
• CaMKIIδ subtypes differentially regulate infarct formation following ex vivo myocardial ischemia/reperfusion through NF-κB and TNF-α.
• Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca(2+) release.
• S100A4 protects the myocardium against ischemic stress.
• Breaking down the COP9 Signalsome in the heart: how inactivating a protein ubiquitin ligase increases protein ubiquitylation and protects the heart.
• Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes.
• Finding the missing link between the unfolded protein response and O-GlcNAcylation in the heart.
• Roles for ATF6 and the sarco/endoplasmic reticulum protein quality control system in the heart.
• PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity.
• Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage.
• Classic studies of cultured cardiac myocyte hypertrophy: interview with a transformer.
• Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1.
• Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1.
• New concepts of endoplasmic reticulum function in the heart: programmed to conserve.
• ATF6 [corrected] and thrombospondin 4: the dynamic duo of the adaptive endoplasmic reticulum stress response.
• Roles for the sarco-/endoplasmic reticulum in cardiac myocyte contraction, protein synthesis, and protein quality control.
• Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response.
• Clarifying the cardiac proteasome paradox: protein quality control.
• Protein disulfide isomerase-associated 6 is an ATF6-inducible ER stress response protein that protects cardiac myocytes from ischemia/reperfusion-mediated cell death.
• Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco/endoplasmic reticulum calcium depletion.
• Regulation of microRNA expression in the heart by the ATF6 branch of the ER stress response.
• Functions for the cardiomyokine, MANF, in cardioprotection, hypertrophy and heart failure.
• The cardiokine story unfolds: ischemic stress-induced protein secretion in the heart.
• Pim-1 kinase protects mitochondrial integrity in cardiomyocytes.
• Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart.
• Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response.
• The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels.
• LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection.
• Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart.
• Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene.
• The role of the unfolded protein response in the heart.
• Pim-1 regulates cardiomyocyte survival downstream of Akt.
• Endoplasmic reticulum stress in the heart.
• Getting a G--RRP on regulated exocytosis in the heart.
• Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability.
• Alterations in oxidative phosphorylation complex proteins in the hearts of transgenic mice that overexpress the p38 MAP kinase activator, MAP kinase kinase 6.
• Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes.
• Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6.
• Atrial natriuretic peptide promotes cardiomyocyte survival by cGMP-dependent nuclear accumulation of zyxin and Akt.
• Activation of p38 has opposing effects on the proliferation and migration of endothelial cells.
• Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo.
• Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction.
• Roles for alphaB-crystallin and HSPB2 in protecting the myocardium from ischemia-reperfusion-induced damage in a KO mouse model.
• The MKK6-p38 MAPK pathway prolongs the cardiac contractile calcium transient, downregulates SERCA2, and activates NF-AT.
• Factor associated with neutral sphingomyelinase activation and its role in cardiac cell death.
• MAP kinase kinase 6-p38 MAP kinase signaling cascade regulates cyclooxygenase-2 expression in cardiac myocytes in vitro and in vivo.
• Expression and functional characterization of SCaMPER: a sphingolipid-modulated calcium channel of cardiomyocytes.
• Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis.
• Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16.
• Guanine nucleotide exchange factor-like factor (Rlf) induces gene expression and potentiates alpha 1-adrenergic receptor-induced transcriptional responses in neonatal rat ventricular myocytes.