Donna J. Thuerauf
Optimizing Adeno-Associated Virus Serotype 9 for Studies of Cardiac Chamber-Specific Gene Regulation.
The peroxisomal enzyme, FAR1, is induced during ER stress in an ATF6-dependent manner in cardiac myocytes.
Proteomic analysis of the cardiac myocyte secretome reveals extracellular protective functions for the ER stress response.
Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart.
ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb.
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis.
ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart.
Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca(2+) release.
S100A4 protects the myocardium against ischemic stress.
Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes.
PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity.
Mechanistic target of rapamycin complex 2 protects the heart from ischemic damage.
Pathological hypertrophy amelioration by PRAS40-mediated inhibition of mTORC1.
Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1.
Protein disulfide isomerase-associated 6 is an ATF6-inducible ER stress response protein that protects cardiac myocytes from ischemia/reperfusion-mediated cell death.
Mesencephalic astrocyte-derived neurotrophic factor protects the heart from ischemic damage and is selectively secreted upon sarco/endoplasmic reticulum calcium depletion.
Regulation of microRNA expression in the heart by the ATF6 branch of the ER stress response.
Roles for endoplasmic reticulum-associated degradation and the novel endoplasmic reticulum stress response gene Derlin-3 in the ischemic heart.
Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response.
The ATF6-MetVal substitution is associated with increased plasma cholesterol levels.
Mesencephalic astrocyte-derived neurotrophic factor is an ischemia-inducible secreted endoplasmic reticulum stress response protein in the heart.
Coordination of growth and endoplasmic reticulum stress signaling by regulator of calcineurin 1 (RCAN1), a novel ATF6-inducible gene.
Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability.
Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes.
Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction.
MAP kinase kinase 6-p38 MAP kinase signaling cascade regulates cyclooxygenase-2 expression in cardiac myocytes in vitro and in vivo.
Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis.
Coordination of ATF6-mediated transcription and ATF6 degradation by a domain that is shared with the viral transcription factor, VP16.