"Gene Silencing"

Limitation of individual folding resources in the ER leads to outcomes distinct from the unfolded protein response.

ER stress leads to upregulation of multiple folding and quality control components, known as the unfolded protein response (UPR). Glucose Regulated Protein 78 (GRP78) (also known as binding immunoglobulin protein, BiP, and HSPA5) and GRP94 are often …