"Muscle Proteins/*biosynthesis"

Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca(2+) release.

BACKGROUND: Junctophilin-2 (JPH2) is the primary structural protein for the coupling of transverse (T)-tubule associated cardiac L-type Ca channels and type-2 ryanodine receptors on the sarcoplasmic reticulum within junctional membrane complexes …

Roles for ATF6 and the sarco/endoplasmic reticulum protein quality control system in the heart.

The hypertrophic growth of cardiac myocytes is a highly dynamic process that underlies physiological and pathological adaptation of the heart. Accordingly, a better understanding of the molecular underpinnings of cardiac myocyte hypertrophy is …